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兜甲蛋白抗體
  • 產(chǎn)品貨號：
    BN40513R
  • 中文名稱：
    兜甲蛋白抗體
  • 英文名稱：
    Rabbit anti-LOR/Loricrin Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40513R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Horse) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40513R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Horse) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱LOR/Loricrin
中文名稱兜甲蛋白抗體
別    名LOR; LOR protein; LORI_HUMAN; Loricrin; LRN; MGC111513; OTTHUMP00000015823.  


研究領(lǐng)域細(xì)胞生物  免疫學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Horse, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量26kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LOR/Loricrin:251-312/312 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]

Function:
Major keratinocyte cell envelope protein.

Subcellular Location:
Cytoplasm. Nucleus；nucleoplasm.

Post-translational modifications:
Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
Contains inter- or intramolecular disulfide-bonds.

DISEASE:
Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.

SWISS:
P23490

Gene ID:
4014

Database links:

Entrez Gene: 4014 Human

Entrez Gene: 16939 Mouse

Entrez Gene: 502541 Rat

Omim: 152445 Human

SwissProt: P23490 Human

SwissProt: P18165 Mouse

Unigene: 251680 Human

Unigene: 1121 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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